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  • Title: Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.
    Author: Wegner CD, Gundel RH, Reilly P, Haynes N, Letts LG, Rothlein R.
    Journal: Science; 1990 Jan 26; 247(4941):456-9. PubMed ID: 1967851.
    Abstract:
    Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo. In a primate model of asthma, a monoclonal antibody to ICAM-1 attenuated airway eosinophilia and hyperresponsiveness. Thus, antagonism of ICAM-1 may provide a therapeutic approach to reducing airway inflammation, hyperresponsiveness, and asthma symptoms.
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