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  • Title: Xanthanolides with antitumour activity from Xanthium italicum.
    Author: Kovács A, Vasas A, Forgo P, Réthy B, Zupkó I, Hohmann J.
    Journal: Z Naturforsch C J Biosci; 2009; 64(5-6):343-9. PubMed ID: 19678536.
    Abstract:
    Bioassay-guided fractionation of a CHCl3 extract of the leaves of Xanthium italicum Moretti led to the isolation of four xanthanolides: xanthatin (1), 4-epixanthanol (2), 4-epi-isoxanthanol (3), and 2-hydroxyxanthinosin (4). Their structures were determined by means of 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, which resulted in complete and unambiguous 1H and 13C NMR chemical shift assignments. The isolated compounds 1-4 were evaluated for their antiproliferative activities, and were demonstrated to exert significant cell growth inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF7) cells.
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