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  • Title: Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field.
    Author: Wang W, Wang Y, Tao H, Peng X, Liu P, Zhu W.
    Journal: J Nat Prod; 2009 Sep; 72(9):1695-8. PubMed ID: 19685913.
    Abstract:
    In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 muM.
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