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  • Title: Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd.
    Author: Nichols B.
    Journal: J Cell Biol; 2009 Aug 24; 186(4):457-9. PubMed ID: 19687254.
    Abstract:
    Endocytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched early endosomal compartments (GEECs) has been proposed. How sorting into this pathway may take place is unclear. In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits.
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