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  • Title: Fatal TRALI associated with neutrophil antibodies in a recipient of pre-storage leukocyte-reduced blood components.
    Author: Ishii K, Kadota E, Shimizu M, Nomura S.
    Journal: Intern Med; 2009; 48(16):1429-31. PubMed ID: 19687592.
    Abstract:
    A 53-year-old man developed possible transfusion-related acute lung injury (TRALI) after red cell component transfusion. The patient developed autoimmune neutropenia with the expression of neutrophil antibodies. Neutrophil aggregation, endothelial damage, and development of a large thrombus containing platelets were observed post mortem in his pulmonary vessels. The patient also had subacute organizing pneumonia. He received blood components treated with universal pre-storage leuko-reduction. Even though leukocytes in the blood components are reduced to a few million by this process, TRALI can be fatal, as was the case for this recipient, who had subacute organizing pneumonia in conjunction with immune-mediated neutropenia.
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