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  • Title: [HPLC-MS analysis of quercetin and its metabolites in portal vein after intragastrical administration of quercetin in rats].
    Author: An D, Wu S, Wei J, Yang J.
    Journal: Wei Sheng Yan Jiu; 2009 Jul; 38(4):417-9. PubMed ID: 19689070.
    Abstract:
    OBJECTIVE: To analyse the plasma contents of querceitn and its metabolites in portal vein in rats. METHODS: Male Wistar rats were orally administrated with quercetin at the dose of 40 mg/kg. The blood samples were corrected from the portal vein 1 h later. The quercetin and its metabolites in plasma were analysed with high performance liquid chromatography-mass spetrometry (HPLC-MS) method. RESULTS: The quercetin, quercetin-3-glucuronide, quercetin glucuronide sulfate, 3'-O-methylated quercetin, 4'-O- methylated quercetin and quercetin sulfate were detected in portal vein. CONCLUSION: The results indicated that the quercetin was extensively metabolized in intestine and entered the portal vein in various forms after administration.
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