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  • Title: Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents.
    Author: Agarwal KC, Sharma V, Shakya N, Gupta S.
    Journal: Bioorg Med Chem Lett; 2009 Sep 15; 19(18):5474-7. PubMed ID: 19692240.
    Abstract:
    4-(Substituted-benzylidine)-2-substituted-5,6-dihydrobenzo[h]quinazoline (5a-p) and 4-(substituted-benzylidine)-2-substituted-3, 4, 5, 6-tetrahydrobenzo[h]quinazoline (6a-p) have been synthesized from 2-(substituted-benzylidine)tetralone-1(3a-d) and several substituted guanidine sulfates(4a-d).These compounds were tested for their in vitro antileishmanial activity. The compounds 6i, 6f, 6g show promising antileishmanial activity against Leishmania donovani.
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