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  • Title: Chronic myelogenous leukemia and benzene exposure: a systematic review and meta-analysis of the case-control literature.
    Author: Lamm SH, Engel A, Joshi KP, Byrd DM, Chen R.
    Journal: Chem Biol Interact; 2009 Dec 10; 182(2-3):93-7. PubMed ID: 19695237.
    Abstract:
    Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p=0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
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