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  • Title: "Primary" leptomeningeal medulloblastoma.
    Author: Mehta RI, Cutler AR, Lasky JL, Yong WH, Lerner JT, Hirota BK, Salamon N, Mathern GW, Vinters HV.
    Journal: Hum Pathol; 2009 Nov; 40(11):1661-5. PubMed ID: 19695677.
    Abstract:
    We report the case of an 8-year-old boy who presented with a 2-month history of headaches and mild visual impairment and was found to have a medulloblastoma with primary leptomeningeal involvement. No mass lesion was found on imaging studies, during subsequent intraoperative surgical inspection or at autopsy. The pathologic findings were first documented on cerebrospinal fluid cytologic examination and biopsy of the cerebellum and were later confirmed at necropsy. To our knowledge, this is the third reported case of medulloblastoma identified with primary leptomeningeal involvement without a cerebellar mass and the first such case with documented autopsy findings.
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