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  • Title: The diagnostic significance of hCG and hPL via immunohistochemistry of placental tissues in pregnancies diagnosed with IUGR and IUD.
    Author: Günyeli I, Zergeroğlu S, Danişman N, Mollamahmutoğlu L.
    Journal: J Obstet Gynaecol; 2009 Aug; 29(6):521-5. PubMed ID: 19697201.
    Abstract:
    Placentas of patients diagnosed with intrauterine growth restriction (IUGR) and intrauterine death (IUD) were examined by immunohistochemistry for alpha-beta subunits of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) antibodies, and compared with placentas from women with healthy pregnancies. In total, 114 subjects were evaluated. The patient group comprised 27 cases of IUGR and 57 of IUD, and the control group consisted of 30 women with normal pregnancies. Placental specimens were examined for primary antibodies using immunohistochemical techniques. Placentas from 22 cases of IUGR were stained positively for alpha-hCG. All 27 specimens obtained from this group were stained positively for beta-hCG and hPL. Among the cases of IUD, 44 placentas were stained positively for alpha-hCG, and all 57 specimens were stained positively for beta-hCG and hPL.
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