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  • Title: Progestin and antiprogestin interactions with progesterone receptors in human myomas.
    Author: Vij U, Murugesan K, Laumas KR, Farooq A.
    Journal: Int J Gynaecol Obstet; 1990 Apr; 31(4):347-53. PubMed ID: 1969820.
    Abstract:
    Progesterone receptors (PRs) in human fibromyomata (myomas) and normal myometrium were characterized by gel filtration, sucrose gradient sedimentation analysis, isoelectrofocusing and ligand specificity. The PR population in myoma tissues, 1242 +/- 505 fmol/mg protein, was 3-fold higher than normal myometrial tissues under similar hormonal milieu. The increased PR concentration in myomas appears to be of potential importance in physiopathology of fibromyoma.
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