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  • Title: Effect of plasma lipoproteins and their complexes with polysaccharides on interleukin-1beta concentration in macrophages of mice with HA-1 ascitic hepatoma.
    Author: Polyakov LM, Sumenkova DV, Panin LE.
    Journal: Bull Exp Biol Med; 2009 Apr; 147(4):466-8. PubMed ID: 19704950.
    Abstract:
    Experiments on cultured peritoneal macrophage from mice with HA-1 ascitic hepatoma showed that plasma lipoproteins present in the incubation medium decreased intracellular concentration of interleukin-1beta. These changes were most pronounced for high-density lipoproteins (alone or in combination with cortisol). Bacterial and yeast polysaccharides had little effect on interleukin-1beta concentration in macrophages. Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1beta concentration. A combination of polysaccharides and high-density lipoproteins had the strongest effect. These properties of plasma lipoproteins should be taken into account in the correction of macrophage function during tumor growth.
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