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  • Title: Automated laser guidance of neuronal growth cones using a spatial light modulator.
    Author: Carnegie DJ, Cizmár T, Baumgartl J, Gunn-Moore FJ, Dholakia K.
    Journal: J Biophotonics; 2009 Nov; 2(11):682-92. PubMed ID: 19705368.
    Abstract:
    The growth cone of a developing neuron can be guided using a focused infra-red (IR) laser beam [1]. In previous setups this process has required a significant amount of user intervention to adjust continuously the laser beam to guide the growing neuron. Previously, a system using an acousto-optical deflector (AOD) has been developed to steer the beam [2]. However, to enhance the controllability of this system, here we demonstrate the use of a computer controlled spatial light modulator (SLM) to steer and manipulate the shape of a laser beam for use in guided neuronal growth. This new experimental setup paves the way to enable a comprehensive investigation into beam shaping effects on neuronal growth and we show neuronal growth initiated by a Bessel light mode. This is a robust platform to explore the biochemistry of this novel phenomenon.
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