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  • Title: Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes.
    Author: Guimond N, Fagnou K.
    Journal: J Am Chem Soc; 2009 Sep 02; 131(34):12050-1. PubMed ID: 19705909.
    Abstract:
    A general rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.
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