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  • Title: [Lung impairment in systemic sclerosis].
    Author: Knoop H, Arinir U, Kreuter A, Walther JW, Schultze-Werninghaus G, Rohde G.
    Journal: Pneumologie; 2009 Sep; 63(9):497-507. PubMed ID: 19708006.
    Abstract:
    Scleroderma is a generic term for autoimmunological diseases having thickened sclerotic skin lesions in common. Scleroderma belongs to a group of connective tissue diseases. The systemic form of scleroderma is called progressive systemic sclerosis (PSS) or systemic sclerosis (SSc). Lung impairments, namely interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), are one of the most common manifestations in SSc. This article summarises the forms of lung impairment in SSc with special emphasis on interstitial lung diseases and draws attention to the so far identified pathogenetic mechanisms and the presently accepted therapeutic options.
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