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  • Title: [Study of gastric APUD cells in gastroduodenal hemorrhage].
    Author: Ratner GL, Kvetnoĭ IM, Bereslavskiĭ MI, Margolis IaM, Vaĭsman BL.
    Journal: Khirurgiia (Mosk); 1990 Feb; (2):89-93. PubMed ID: 1970840.
    Abstract:
    It was found that in patients with gastroduodenal hemorrhage the number of serotonin-, histamine-, and melatonin-producing apudocytes in the gastric mucosa increases while the number of cells producing gastrin, adrenaline, and noradrenaline reduces. In timely arrest of hemorrhage, the primarily increased number of melatonin-producing apudocytes diminishes with time from the onset of bleeding and reaches normal values gradually. The essential differences in the content of melatonin- and noradrenaline- producing apudocytes in patients with and without hemorrhage allow this morphological sign to be used as diagnostic and prognostic criteria in gastroduodenal hemorrhages.
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