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Title: Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles. Author: Tang S, He J, Sun Y, He L, She X. Journal: Org Lett; 2009 Sep 03; 11(17):3982-5. PubMed ID: 19708706. Abstract: A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.[Abstract] [Full Text] [Related] [New Search]