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  • Title: Antigen-specific therapies in multiple sclerosis.
    Author: Giacomini PS, Bar-Or A.
    Journal: Expert Opin Emerg Drugs; 2009 Sep; 14(3):551-60. PubMed ID: 19708820.
    Abstract:
    BACKGROUND: If found to be effective, antigen-specific therapies in MS hold the promise of selectively targeting pathogenic effector cells, while leaving the rest of immune system undisturbed. OBJECTIVE: To review the principles and challenges of antigen-specific therapies of the past and those presently under development, and how the lessons learnt can guide us moving forward. METHODS: We review past and current antigen-specific strategies for the treatment of MS, including their successes and challenges, as well as the lessons we have learnt from them about MS pathophysiology. RESULTS: Several antigen-specific therapies may accomplish the desired balance between safety and efficacy, although significant challenges remain for this class of therapeutics.
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