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  • Title: Synthesis and antitubercular activity of novel Schiff bases derived from d-mannitol.
    Author: Ferreira Mde L, Vasconcelos TR, de Carvalho EM, Lourenço MC, Wardell SM, Wardell JL, Ferreira VF, de Souza MV.
    Journal: Carbohydr Res; 2009 Oct 12; 344(15):2042-7. PubMed ID: 19709650.
    Abstract:
    Six Schiff base derivatives of d-mannitol, 1,6-dideoxy-1,6-bis-{[(E)-arylmethylidene]amino}-d-mannitol (6: aryl=XC(6)H(4): X=o-, m- and p- Cl or NO(2)), have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. All three nitro derivatives exhibit significant activities: activities of (6d: X=o-NO(2)), (6e: X=m-NO(2)) and (6f: X=p-NO(2)) are 12.5, 25.0 and 25.0microg/mL, respectively. When compared with first line drugs, such as ethambutol, they can be considered as a good starting point to develop new lead compounds for the treatment of multidrug-resistant tuberculosis. Characterization of the new compounds 6 is generally achieved spectroscopically. The structure of compound 3 has been confirmed by X-ray crystallography.
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