These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Neurohumoral pathways mediating stress-induced inhibition of gastric acid secretion in rats.
    Author: Lenz HJ, Drüge G.
    Journal: Gastroenterology; 1990 Jun; 98(6):1490-2. PubMed ID: 1970968.
    Abstract:
    In awake rats, physical restraint inhibited pentagastrin-stimulated gastric acid secretion by more than 50%. This inhibitory effect was abolished by either ganglionic or noradrenergic blockade. Adrenalectomy, as well as pretreatment with a vasopressin V1-receptor antagonist, significantly attenuated the gastric inhibitory effect in response to stress. In contrast, neither truncal vagotomy nor hypophysectomy or opiate blockade prevented stress-induced inhibition of gastric acid secretion. These findings indicate that stress-induced inhibition of gastric acid secretion in rats is mediated by autonomic, noradrenergic efferents as well as by adrenal and vasopressin-dependent pathways. Vagal efferents, opiate pathways, and the pituitary gland do not seem to be involved.
    [Abstract] [Full Text] [Related] [New Search]