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  • Title: Effects of terazosin on serum lipid levels in hypertensive blacks.
    Author: Luther RR, Klepper MJ, Maurath CJ, Glassman HN, Achari R, Laddu AR.
    Journal: J Hum Hypertens; 1990 Apr; 4(2):154-6. PubMed ID: 1971028.
    Abstract:
    The effects of terazosin, a new, selective, alpha 1-adrenoceptor antagonist, on the serum lipid levels were examined in 103 black patients with uncomplicated, mild to moderate essential hypertension in six randomized, double-blind, placebo-controlled trials conducted in the United States. Terazosin produced statistically significant (P less than 0.05) reductions in total serum cholesterol and triglyceride levels and a marginally significant (P = 0.080) reduction in the combined low-density lipoprotein (LDL-C) and very-low-density lipoprotein (VLDL-C) cholesterol fraction when compared with placebo. We conclude that terazosin, unlike thiazide diuretics, has a favourable effect on the serum lipid profiles of hypertensive blacks.
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