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  • Title: [Effect of intermittent hypergravity on cerebellum Purkinje's cells in suspended rats].
    Author: Krasnov IB, Krasnikov GV, Chel'naia NA.
    Journal: Aviakosm Ekolog Med; 2009; 43(3):39-43. PubMed ID: 19711861.
    Abstract:
    The quantitative cytochemical and morphometrical techniques applied in the experiment with 24-d tail-suspension of rats demonstrated a decrease of cytochrome oxidase activity and downsizing of Purkinje's cell bodies in the proprioceptive cerebellum (cerebellar vermis upper central lobule), as well as a decrease of cytochrome oxidase activity in Purkinje's cells in the vestibular cerebellum (nodulus). The observed suppression of the Purkinje's cells functional activity indicates reductions in the proprioceptive and vestibular afferent inputs to these cells during simulation of the microgravity effects in rats. Intermittent exposure to hypergravity (2 G, one hour a day) prevented the decreases in cytochome oxidase activity in Purkinje's cells of both the proprioceptive and vestibular cerebella of tail-suspended rats suggesting a nearly same level of functioning as in the vivarium controls.
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