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  • Title: Synthesis and cytotoxicity studies of new cryptophycin analogues.
    Author: Liu WL, Zhang JC, Jiang FQ, Fu L.
    Journal: Arch Pharm (Weinheim); 2009 Oct; 342(10):577-83. PubMed ID: 19714674.
    Abstract:
    Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.
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