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  • Title: Heparin and maternal fetal interface: why should it work to prevent pregnancy complications?
    Author: Hossain N, Schatz F, Paidas MJ.
    Journal: Thromb Res; 2009 Dec; 124(6):653-5. PubMed ID: 19716166.
    Abstract:
    Anticoagulant therapy has been used extensively for the prevention of recurrent pregnancy losses, and other placenta mediated complications, including prevention of preeclampsia and fetal growth restriction. While heparin anticoagulation is a standard treatment for antiphospholipid antibody syndrome, it is increasingly being used in the prevention of placenta mediated complications. In this article, we explore the role of heparin at maternal-fetal interface, the molecular mechanism of action for heparin, and ongoing basic and translational work being done to elucidate heparin's principal mechanisms of action.
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