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  • Title: Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines.
    Author: Phutdhawong WS, Ruensamran W, Phutdhawong W, Taechowisan T.
    Journal: Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5753-6. PubMed ID: 19716300.
    Abstract:
    A rapid route to a series of naphthoquinone-fused indole derivatives via irradiation in a modified commercial domestic microwave is reported. The desired products were produced in high yields and short reaction times. The naphthoquinone-fused indole derivatives were evaluated for their pro-inflammatory cytokines responses using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. The results showed that most of the tested compounds inhibit the production of nitric oxide (NO), prostaglandin (PG)E(2), tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in RAW264.7 cells treated with LPS.
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