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  • Title: Intramolecular pyridine activation-dearomatization reaction: highly stereoselective synthesis of polysubstituted indolizidines and quinolizidines.
    Author: Barbe G, Pelletier G, Charette AB.
    Journal: Org Lett; 2009 Aug 06; 11(15):3398-401. PubMed ID: 19719187.
    Abstract:
    An unprecedented intramolecular pyridine activation-asymmetric dearomatization reaction is described. This process produces 5-substituted indolizidines and 6-substituted quinolizidines in excellent yields and in a highly regio- and diastereoselective fashion. Formal syntheses of trans-indolizidine alkaloids are presented along with some preliminary results in the formation of C-5 quaternary centers.
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