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  • Title: Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.
    Author: Lebold TP, Leduc AB, Kerr MA.
    Journal: Org Lett; 2009 Aug 20; 11(16):3770-2. PubMed ID: 19719208.
    Abstract:
    The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf(2))(2) allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia-ene cyclization.
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