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  • Title: Three adducts of butenolide and apigenin glycoside from the leaves of Machilus japonica.
    Author: Lee SS, Lin YS, Chen CK.
    Journal: J Nat Prod; 2009 Jul; 72(7):1249-52. PubMed ID: 19719245.
    Abstract:
    Chemical investigation of the EtOH extract of the leaves of Machilus japonica var. kusanoi resulted in the isolation of three compounds with a unique skeleton, i.e., apigenosylides A-C (4-6), together with five known flavonoid glycosides. Some of these compounds possess moderate inhibitory activity against alpha-glucosidase. The structures of the new compounds were elucidated on the basis of spectrometric analyses. They possess an unprecedented skeleton comprising the adduct of a butenolide moiety and apigenin glycoside linked via a 1,2-dioxane moiety.
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