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  • Title: Homeodomain binding sites in the 5' flanking region of the Bombyx mori silk fibroin light-chain gene.
    Author: Hui CC, Suzuki Y, Kikuchi Y, Mizuno S.
    Journal: J Mol Biol; 1990 Jun 05; 213(3):395-8. PubMed ID: 1972197.
    Abstract:
    Multiple A + T-rich stretches in the 5' flanking region of the Bombyx mori fibroin light-chain gene have been shown to bind two Drosophila homeodomain proteins, EVE (even-skipped) and ZEN (zerknüllt), with high affinities. Some of these sites fall into a class that has the established consensus sequence of the binding sites (TCAATTAAAT) for a diverse group of Drosophila homeodomain proteins, while others are quite heterogenous except that they all possess a core TAAT motif. Since clusters of homeodomain binding sites can also be found in the promoters of other silk protein genes, the fibroin gene and the sericin-1 gene, these observations suggest a possible involvement of some homeobox genes in the regulation of a group of silk protein genes.
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