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  • Title: Nucleic acid-induced aggregation and pyrene excimer formation.
    Author: Zhang R, Tang D, Lu P, Yang X, Liao D, Zhang Y, Zhang M, Yu C, Yam VW.
    Journal: Org Lett; 2009 Oct 01; 11(19):4302-5. PubMed ID: 19722507.
    Abstract:
    Nucleic acid was found to induce the aggregation of the positively charged pyrene probe (compound 1); as a result, strong pyrene excimer emission was observed. The intensity of the excimer emission was dependent on the concentration of the pyrene probe and the oligonucleotide length, sequence, and concentration. These results suggest a new strategy for label-free nucleic acid-based biosensing applications.
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