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  • Title: Cr(III)(salen)Cl catalyzed enantioselective intramolecular addition of tertiary enamides to ketones: a general access to enantioenriched 1H-pyrrol-2(3H)-one derivatives bearing a hydroxylated quaternary carbon atom.
    Author: Yang L, Wang DX, Huang ZT, Wang MX.
    Journal: J Am Chem Soc; 2009 Aug 05; 131(30):10390-1. PubMed ID: 19722618.
    Abstract:
    Catalyzed by a chiral Cr(III)(salen)Cl complex 3e, tertiary enamides 1 underwent an efficient and enantioselective intramolecular addition reaction to an activated carbonyl moiety to produce in excellent yield highly enantioenriched 1H-pyrrol-2(3H)-one derivatives 2 that bear a hydroxylated quaternary carbon atom. The synthetic application of resulting compounds has been demonstrated in the synthesis of (3S,5S)-3,5-diphenyl-3-pyrrolidinol.
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