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  • Title: Leukocyte elastase inhibitor: a new regulator of PARP-1.
    Author: Leprêtre C, Sidoli G, Scovassi AI, Torriglia A.
    Journal: Ann N Y Acad Sci; 2009 Aug; 1171():25-31. PubMed ID: 19723034.
    Abstract:
    Poly(ADP-ribose) polymerase-1 (PARP-1) uses NAD(+) as a substrate to form ADP-ribose. During apoptosis, caspases cleave PARP-1 to avoid excessive NAD consumption. Because PARP-1 is a key regulator of the activity of DNases involved in caspase-dependent apoptosis, its cleavage is required to promote DNA degradation. To explore the situation in caspase-independent cell death, we investigated the effect of PARP-1 on the acid endonuclease leukocyte elastase inhibitor (LEI)-derived DNase II (L-DNase II). We found for the first time an association between PARP-1 and LEI/L-DNase II. Unexpectedly, we observed that LEI influenced the automodification of PARP-1.
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