These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of blockade of tumor necrosis factor-alpha with etanercept on surgical wound healing in SWISS-OF1 mice.
    Author: Iglesias E, O'Valle F, Salvatierra J, Aneiros-Fernández J, Cantero-Hinojosa J, Hernández-Cortés P.
    Journal: J Rheumatol; 2009 Oct; 36(10):2144-8. PubMed ID: 19723900.
    Abstract:
    OBJECTIVE: To assess whether blockade of tumor necrosis factor-alpha (TNF-alpha) influences surgical wound healing in a normal mouse experimental model. METHODS: Wound healing time course and degree of surgical wound collagenization were measured by morphological techniques and digital image analysis in 80 male SWISS-OF1 mice (40 received subcutaneous etanercept at a dose of 0.1 mg/25 g/ at -7, 0, 7, and 14 days). RESULTS: No significant differences were observed between treated and untreated animals in wound healing, re-epithelialization, or formation of inflammatory infiltrate or granulation tissue at days 7, 15, or 20 after surgery. At 20 days, the collagen area was larger in treated versus untreated mice (109,029 +/- 28,489 microm(2) vs 79,305 +/- 19,798 microm(2), p = 0.026, Mann-Whitney U test). CONCLUSION: Surgical wounds showed a higher degree of collagenization at 20 days in etanercept-treated versus untreated mice, with no differences in the time course of wound healing. These data suggest that biological therapies to block TNF-alpha do not affect wound healing and do not need to be suspended during the perioperative period.
    [Abstract] [Full Text] [Related] [New Search]