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  • Title: Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
    Author: Iino T, Sasaki Y, Bamba M, Mitsuya M, Ohno A, Kamata K, Hosaka H, Maruki H, Futamura M, Yoshimoto R, Ohyama S, Sasaki K, Chiba M, Ohtake N, Nagata Y, Eiki J, Nishimura T.
    Journal: Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5531-8. PubMed ID: 19726182.
    Abstract:
    We describe design, syntheses and structure-activity relationships of a novel class of 4,6-disubstituted quinazoline glucokinase activators. Prototype quinazoline leads (4 and 5) were designed based on the X-ray analyses of the previous 2-aminobenzamide lead classes. Modifications of the quinazoline leads led to the identification of a potent GK activator (21d).
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