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  • Title: [Expression of aquaporin-1 in human oligohydramnios placenta and fetal membranes].
    Author: Hao RZ, Liu HS, Xiong ZF.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2009 Jun; 29(6):1130-2. PubMed ID: 19726340.
    Abstract:
    OBJECTIVE: To detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes. METHODS: Placenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume. AQP-1 mRNA expression in the tissue samples was detected by semi-quantitative RT-PCR. RESULTS: The expression of AQP1 mRNA was significantly lower in oligohydramnios placenta than in normal pregnancy placenta at term (P<0.05), and also significantly lower in oligohydramnios fetal membranes than in normal fetal membranes at term (P<0.05). CONCLUSION: Alterations in AQP1 mRNA expressions in human placenta and fetal membranes may play an important role in the disorder of maternal-fetal fluid exchange and amniotic fluid volume.
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