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  • Title: Effects of somatostatin-28 and some of its fragments and analogs on open-field behavior, barrel rotation, and shuttle box learning in rats.
    Author: Vécsei L, Widerlöv E.
    Journal: Psychoneuroendocrinology; 1990; 15(2):139-45. PubMed ID: 1972798.
    Abstract:
    The effect of intracerebroventricular (ICV) administration of somatostatin-28 (SS-28) and some of its fragments, SS-28 (1-12), SS-28(15-28), and analogs, des-AA-(1,2,4,5,12,13)-(DTrp8)SS-14, ODT8-SS, and (DTrp8,DCys14)SS-14 were studied in different behavioral tests on rats. SS-28 (6.0 nM) decreased, SS-28(15-28) (0.6 nM) increased, and SS-28(15-28) (6.0 nM) decreased activity of the animals in an open-field test. SS-28(1-12) (0.6, 3.0, and 6.0 nM) did not influence this behavior. ODT8-SS (0.6, 3.0, and 6.0 nM) decreased activity of the rats, while (DTrp8,DCys14)SS-14 increased it, only at a high dose (6.0 nM). Similar results were obtained for barrel rotation, except that (DTrp8,DCys14)SS-14 even in high dose (12.0 nM) had no effect. In a shuttle-box learning paradigm, SS-28(15-28) (0.6 nM) facilitated, while SS-28(1-12) (0.6 nM) did not influence, the performance of the animals. These results suggest that the isomeric Cys(28) form of the SS-28(15-28) molecule may be crucial for the expression of the behavioral effects of these peptides.
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