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  • Title: Quinine and quinidine cross-react after systemic photosensitization in the mouse.
    Author: Wirestrand LE, Ljunggren B.
    Journal: Acta Derm Venereol; 1990; 70(3):204-7. PubMed ID: 1972831.
    Abstract:
    Using a protocol for induction of photoallergy in the mouse after systemic administration, quinine was shown to be just as potent a photosensitizer as its d-isomer, quinidine. The dose-response curves for the two isomers followed a similar course both for induction and elicitation. Cross-reaction experiments, where induction and challenge were performed with different isomers, indicated that quinine and quinidine cross-react. Traces of the isomer as a contaminant in the test compound are not likely to account for this cross-reactivity. For practical purposes, photosensitization to one of these two quinoline methanol isomers seems to exclude the future use of the other.
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