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  • Title: Melanoma promotion after photodynamic therapy of a suspected Bowen's disease lesion.
    Author: Schreml S, Gantner S, Steinbauer J, Babilas P, Landthaler M, Szeimies RM.
    Journal: Dermatology; 2009; 219(3):279-81. PubMed ID: 19729877.
    Abstract:
    We report on a 61-year-old male patient who developed a melanoma at the site of a suspected Bowen's lesion on the right cheek. This lesion had evolved for years and had been treated using photodynamic therapy (PDT) in an outpatient facility. Only a couple of months after a single PDT treatment, a melanoma was histologically diagnosed. After excision, multiple metastases were found. The therapeutic strategy comprised re-excision, neck dissection and lateral parotidectomy - due to a metastasis - as well as subsequent alpha-interferon injections. The possible role of PDT in the promotion of melanoma is discussed.
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