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  • Title: A 5-year-old boy with unicentric Castleman disease affecting the mesentery: utility of serum IL-6 level and (18)F-FDG PET for diagnosis.
    Author: Toita N, Kawamura N, Hatano N, Takezaki S, Ohkura Y, Yamada M, Okano M, Okada T, Sasaki F, Kubota KC, Itoh T, Ariga T.
    Journal: J Pediatr Hematol Oncol; 2009 Sep; 31(9):693-5. PubMed ID: 19730402.
    Abstract:
    Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It is quite difficult to diagnose CD without typical localized signs or symptoms. We present a 5-year-old boy with unicentric plasma cell CD in the mesentery, which was too small to be detected by any conventional imaging. (18)F-fluorodeoxyglucose positron emission tomography image and a serum cytokine profile prompted us to perform a curative surgical excision, confirming his diagnosis. Our case also supported an important role of interleukin-6 in the pathophysiology of plasma cell CD.
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