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Title: Highly selective and sensitive heparin probing from supramolecular assembly of pyrene derivatives. Author: Zeng L, Wang P, Zhang H, Zhuang X, Dai Q, Liu W. Journal: Org Lett; 2009 Oct 01; 11(19):4294-7. PubMed ID: 19731922. Abstract: A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for heparin over other biological molecules. Upon binding with heparin, PQ shows a typical excimer emission peaked at 489 nm along with a weak monomer emission at 376 nm. Moreover, PQ also shows good performance to detect the heparin in serum.[Abstract] [Full Text] [Related] [New Search]