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  • Title: Predictive value of osteocalcin in bone metastatic differentiated thyroid carcinoma.
    Author: Gao Y, Lu H, Luo Q, Wu X, Sheng S.
    Journal: Clin Biochem; 2010 Feb; 43(3):291-5. PubMed ID: 19732762.
    Abstract:
    OBJECTIVES: To evaluate the diagnostic value of serum osteocalcin in the detection of bone metastases from differentiated thyroid carcinoma (DTC). DESIGN AND METHODS: Serum samples from DTC patients with (DTC BM+, n=19) or without bone metastases (DTC BM-, n=19), and matched healthy volunteers (n=30) were tested for serum osteocalcin with electrochemiluminescent immunoassay. RESULTS: Osteocalcin was higher in DTC BM+ than in DTC BM- patients (+35.8%, p=0.002), acting as an independent risk factor for bone metastases (R(2)=0.142, p=0.039). The sensitivity was 78.9% and the specificity was 63.2% at a cut-off value of 11.2 microg/L. CONCLUSIONS: Serial measurements of osteocalcin could be useful in the detection of bone metastases from DTC.
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