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  • Title: Effect of a dentifrice containing the peptide of streptococcal antigen I/II on the adherence of mutans streptococcus.
    Author: Li MY, Wang J, Lai GY.
    Journal: Arch Oral Biol; 2009 Nov; 54(11):1068-73. PubMed ID: 19735908.
    Abstract:
    OBJECTIVE: Antigen I/II of mutans streptococcus (MS) is a surface protein, which binds to salivary receptors. The objective of this study was to study the effect of a peptide corresponding to residues 1025-1044 of antigen I/II and a dentifrice containing peptide on the adherence of MS. METHODS: The peptide was synthesized and included into dentifrice. Anti-adherence experiments of the peptide and a dentifrice containing it were processed in vitro and in vivo. RESULTS: The results showed that the adherence of MS to hydroxyapatite was inhibited by synthetic antigen I/II peptide and also by a dentifrice containing the peptide in vitro. The numbers of MS in plaque from subjects treated with dentifrices containing the peptide for 1 month was significantly reduced compared to baseline (log 3.11+/-0.80 vs log 4.09+/-0.90, P<0.01), whereas the control group showed no reduction. CONCLUSION: The adherence of MS to hydroxyapatite was inhibited by both a synthetic peptide and a dentifrice containing the peptide. The peptide dentifrice produced a significant reduction of MS in dental plaque in vivo.
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