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  • Title: Concentrations of circulating hormones normalized to pulses of a prostaglandin F2alpha metabolite during spontaneous luteolysis in mares.
    Author: Ginther OJ, Beg MA.
    Journal: Theriogenology; 2009 Nov; 72(8):1111-9. PubMed ID: 19735938.
    Abstract:
    The temporal relationships between a pulse of 13,14-dihydro-15-keto-PGF(2alpha) (PGFM) and the concentrations of circulating hormones during the luteolytic period were studied for 11 pulses in 11 mares (Equus caballus) using samples collected hourly. Mean PGFM pulses encompassed 4h before to 4h after the peak, and hormone data were normalized to the PGFM peak (Hour 0). Concentration of progesterone decreased (P < 0.05) between Hours -4 and -3 and continued to decrease linearly throughout the PGFM pulse. The concentrations of cortisol and prolactin increased (P < 0.004) during Hours -4 to 0 and decreased (P < 0.002) during Hours 0 to 4. Estradiol concentration increased (P < 0.02) during Hours -4 to 0 but did not change significantly after Hour 0. Concentrations of follicle-stimulating hormone and luteinizing hormone did not change significantly during the PGFM pulse, and the oxytocin results were equivocal. Percentage of corpus luteum area with color-Doppler signals of blood flow did not change significantly between Hours -4 and 0 and first began to decrease (P < 0.004) between Hours 0 and 2. Results demonstrated that concentrations of progesterone decreased linearly during a PGFM pulse, and cortisol, prolactin, and estradiol increased during the ascending portion of the pulse. The progesterone and gonadotropin results supported the hypothesis that the initial progesterone and gonadotropin increases that have been reported to occur in response to a single bolus luteolytic treatment with prostaglandin F(2alpha) do not occur in response to the natural secretion of prostaglandin F(2alpha).
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