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  • Title: Sister Mary Joseph's nodule: a case of umbilical cutaneous metastasis with signet ring cell histology.
    Author: Zadeh VB, Kadyan R, Al-Abdulrazzaq A, Al-Otaibi S, Sarhan A, Najem N.
    Journal: Indian J Dermatol Venereol Leprol; 2009; 75(5):503-5. PubMed ID: 19736432.
    Abstract:
    The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.
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