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  • Title: [Prevalence of hypokalemia in patients with methylprednisolone pulse therapy].
    Author: Tamez-Pérez HE, Cisneros-Pérez V, Cedillo-Rodríguez JA, Diaz-De-León-González E, Torres-Valenzuela M, Tamez-Peña AL, Forsbach-Sánchez G, Gutiérrez-Hermosillo H.
    Journal: Rev Invest Clin; 2009; 61(3):194-7. PubMed ID: 19736807.
    Abstract:
    OBJECTIVE: To determine the prevalence of hypokalemia in patients with methylprednisolone pulse therapy. DESIGN: We carried out a descriptive, cross-sectional study. MATERIAL AND METHODS: We enrolled 110 outpatients who received pulse doses of 1 g of intravenous methylprednisolone for three consecutive days. Demographic variables, serum electrolytes and an electrocardiogram were documented. RESULTS: The study group consisted of 31 men (28.2%) and 79 women (71.8%). Average age was 40 +/- 13.6 years. Mild hypokalemia was present in 19 patients (17.27% [95% CI 9.75-24.79]); moderate potassium levels were found in just one patient 0.9% [IC 95 0.023-4.96]); no cases of severe hypokalemia occurred. Total prevalence was 18.18% (95% CI 10.5-25.8). There were no significant electrocardiographic changes. DISCUSSION AND CONCLUSION: Mild and moderate hypokalemia was 18.18% without clinical or electrocardiographic consequences. Since there were no cases of severe hypokalemia, close monitoring of potassium levels should be restricted to those patients with other risk factors.
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