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  • Title: Ir-catalyzed oxidative desymmetrization of meso-diols.
    Author: Suzuki T, Ghozati K, Katoh T, Sasai H.
    Journal: Org Lett; 2009 Oct 01; 11(19):4286-8. PubMed ID: 19736916.
    Abstract:
    The catalytic oxidative desymmetrization of meso-diols was realized using a chiral iridium catalyst. In particular, the reaction is effective for the cyclic diols to give the corresponding hydroxy ketones in high chemical yields with high ee's. With this reaction as a key step, a short-step synthesis of common intermediate of ottelione and scyphostatin was achieved.
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