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  • Title: Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and N-bis(trifluoromethyl)alkyl-N'-benzothiazolyl ureas.
    Author: Luzina EL, Popov AV.
    Journal: Eur J Med Chem; 2009 Dec; 44(12):4944-53. PubMed ID: 19740574.
    Abstract:
    A number of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, logGI(50) -7.10), 9c SNB-75 (CNS cancer, logGI(50) -5.84), 9b UO-31 (renal cancer, logGI(50) -5.66), and SR (leukemia, logGI(50) -5.44) human cancer cells.
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