These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pharmacology and treatment of neuropathic pains.
    Author: Jensen TS, Madsen CS, Finnerup NB.
    Journal: Curr Opin Neurol; 2009 Oct; 22(5):467-74. PubMed ID: 19741531.
    Abstract:
    PURPOSE OF REVIEW: This review briefly discusses the definition and clinical presentation of neuropathic pain and highlights recent advances in the treatment of neuropathic pain. RECENT FINDINGS: Recent publications have confirmed the efficacy of tricyclic antidepressants, gabapentin, pregabalin, opioids, and tramadol for various neuropathic pain conditions. Selective serotonin noradrenaline reuptake inhibitors have been found to reduce pain in painful neuropathy. The new anticonvulsant lacosamide may have some effect in painful polyneuropathy, whereas levetiracetam has failed to relieve postmastectomy and spinal cord injury pain. The role of the old anticonvulsant phenytoin is still unsettled. A recent trial has found an effect of cannabinoids also in peripheral neuropathic pain. Various topical treatments such as topical lidocaine, topically applied capsaicin in high concentrations (8%), and botulinum toxin have recently been shown to have a pain-relieving effect in various peripheral neuropathic pain conditions. Spinal cord and transcranial magnetic stimulation are stimulation therapies with some evidence for efficacy. SUMMARY: Treating neuropathic pain remains a great challenge, and the treatment has to be individualized to the single patient, taking into account side effects, pain type, comorbidities, and drug interactions.
    [Abstract] [Full Text] [Related] [New Search]