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  • Title: Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia.
    Author: Zigmond RE, Ben-Ari Y.
    Journal: Proc Natl Acad Sci U S A; 1977 Jul; 74(7):3078-80. PubMed ID: 19742.
    Abstract:
    The effect of synaptic stimulation on tyrosine hydroxylase [tyrosine 3-monooxygenase: L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity in the rat superior cervical ganglion was studied. The preganglionic cervical sympathetic trunk was stimulated unilaterally at 10 Hz for 30 min. Forty-eight hours later tyrosine hydroxylase activity was 33% higher on the stimulated than on the control side. The enzyme activity restimulated than on the control side. The enzyme activity remained elevated in the stimulated ganglia for 2 days. No change was observed in total ganglion protein. Comparable increases in tyrosine hydroxylase activity were observed in anesthetized and conscious animals.
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