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  • Title: [The effects of nizatidine and misoprostol on peptic activity and gastric mucus].
    Author: Grassi SA, Vianello F, Germanà B, Dal Santo P, Faggian D, Battaglia G, Plebani M, Di Mario F, Naccarato R.
    Journal: Medicina (Firenze); 1990; 10(1):29-31. PubMed ID: 1974318.
    Abstract:
    The effects of Nizatidine, an H2-receptor antagonist, and Misoprostol, a PGE1 analogue, on gastric pH, pepsin, pepsinogen group I and N-acetylneuraminic acid concentration were evaluated in a group of 20 patients with duodenal ulcer. Nizatidine decreased pepsin concentration while it increased gastric pH, although not to a significant degree and left pepsinogen group I and N-acetylneuraminic acid concentration unchanged. Misoprostol did not modify gastric pH, pepsin and N-acetylneuraminic acid values but it increased pepsinogen group I levels. These data support the view that H2-receptor antagonists, especially Nizatidine, and Misoprostol do not directly affect pepsin and/or N-acetylneuraminic acid concentration.
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